2008). Interestingly, severe hypertension‐induced LV hypertrophy in APN‐KO mice is associated with a reduced cardiac MMP‐2 expression compared to WT mice (Sam et al. 2010) indicating that APN might also inhibit profibrotic ECM remodeling by up‐regulating expression of collagen‐cleaving MMPs. Here, ANPEP is linked to Hypertension.