Even if we did not exclude that the mut-p53/YAP/TEAD complex is also recruited at the PVT1 promoter level, our data support a mechanism according to which the mut-p53/YAP/TEAD complex works preferentially at the circPVT1 promoter level in the HNSCC context and in strict relation with mut-p53. The gene discussed is PVT1; the disease is head and neck squamous cell carcinoma.