The pharmacological RANKL inhibition in OVX mice models, Therefore, using OPG-Fc administered immediately after the OVX procedure, was associated with increased bone volume and density and increased the biomechanical strength of the vertebrae and the femur neck sites that are prone to fragility fractures in women with postmenopausal osteoporosis [62]. This evidence concerns the gene TNFSF11 and postmenopausal osteoporosis.