SIRT2 and posterior cortical atrophy: The median mRNA expression level is lower in SIRT2 deleted patients compared to the SIRT2 intact group (p = 0.03) (Fig. 2B). Clinical data is available for this dataset and we observed higher clinical stage, greater chance of margin positive status at surgery and a higher likelihood of clinical recurrence in the subset of PCa patients with SIRT2 deletions (Table 2).