SOX9 and melanoma: In support of this hypothesis, by Circularized Chromosome Conformation Capture sequencing (4C–seq), the LINC00673 locus was found to be involved in long-range enhancer-promoter interactions at the SOX9 locus in SOX9-expressed melanoma cells but not in SOX9-inactive cells, consistent with the enhancer-promoter interactions driving SOX9 activation [64].