CLDN14 and nephrolithiasis: One such study conducted by Gudmar et al. [8] identified common, synonymous variants in the CLDN14 gene that were associated with kidney stones, and homozygous carriers of the single nucleotide polymorphism (SNP) rs219780[C] in CLDN14 were estimated to have a 1.64-times greater risk of developing the disease compared to non-carriers.