CD8A and prolymphocytic leukemia: Markers related to T-cell activation, such as CD25, class II HLA-DR, and CD38 may or may not be expressed [1, 2, 9], whereas all T-PLL cases are negative for the T-cell Intracellular Antigen 1(TIA-1), a cytotoxic granule -associated protein expressed by cytotoxic T-cells, even in cases with a CD8+ phenotype [12].