AFP and β-hCG are expressed not only in germ cell tumors, but also in other neoplasms; specifically, increased levels of β-hCG have been found in neuroendocrine tumors, cancers of kidney, lung, head and neck, bladder and GI tract [47–49], while increased levels of AFP have been found in liver diseases [50–51]; on the other hand, LDH is nonspecific and may be discovered in different conditions both benign and malignant (see Table 2). This evidence concerns the gene AFP and testicular germ cell tumor.