There are several approaches that have been found to improve chemosensitivity, these include: (i) TIMP-1-GPI application, [72] (ii) suppressing potential chemoresistant cancer stem cells (CMCs) such as the side population (SP) cells e.g. via TIMP-1-GPI [72], and (iii) interrupting CAM-DR[78] by either homotrimeric collagen type I degradation or inhibiting the PI3K-Akt signalling pathway. This evidence concerns the gene TIMP1 and cancer.