B2R and B1R are highly expressed in cancers of the lung [70], breast [71], prostate [72], gall bladder [73], head and neck squamous cell carcinoma (HNSCC) [74], chondrosarcomas [75], colorectal adenomas [76], clear cell renal carcinoma [77], esophageal squamous cell carcinomas, and astrocytic tumors [78]. This evidence concerns the gene BDKRB2 and head and neck squamous cell carcinoma.