Weber et al. reported that even activation of orphan receptor BRS-3 may contribute to cancer cell proliferation, since the analogue [d-Phe6, β-Ala11, Phe13, Nle14] bombesin (6–14) caused enhanced nuclear oncogene expression, MAPK phosphorylation, and Elk-1 activation in lung cancer cells [144]. The gene discussed is GRP; the disease is lung cancer.