PHGDH and cancer: Here, in order to better understand the substrate and catalytic promiscuity of human PHGDH and to identify other potential roles of PHGDH that might be relevant in diseases, such as cancer, we have developed and applied functional and binding assays for PHGDH, and have solved structures for the catalytic domain in complex with its cofactor NAD+ both alone and together with the substrate analogue L-tartrate.