These cell type-specific effects may reflect the aggressiveness and disease state from where the cells were isolated (HCT116 and HT29 from primary tumor; SW620 from metastatic site) and p53 status of each line (HCT116 p53+/+, HT29 mt R273H, SW620 mt R273H + P309S) [38]. Here, TP53 is linked to neoplasm.