Other up-regulated transcripts included Bmp4 and Tgfβr2, involved in bone morphogenic protein (BMP) and transforming growth factor β (TGFβ) signaling, respectively, as well as alpha B crystallin (Cryab) implicated in CRC distant metastasis [39] and bone marrow stromal cell antigen 2 (Bst2) overexpressed in breast cancer bone metastasis [40]. The gene discussed is CRYAB; the disease is breast cancer.