In particular, the reduction of the activity of the glyconeogenotic enzyme G6Pase and glycolysis is a possible explanation for glycogenosis, as chREBP upregulates hepatic G6Pase and glycolysis proteins (i.e. GLUT2, PKM2) gene expression directly in response to glucose increasing intracellular glucose concentration [37, 38]. This evidence concerns the gene PKM and disorder of glycogen metabolism.