TP53 and cancer: Furthermore, the alterations in CCF in KO mice compared to the lesions of WT mice resemble the effects of the tumor suppressor gene p53 in cancer cells [41] and inversely of the protooncogenic Akt/mTOR pathway, suggesting that chREBP suppresses p53 activity and switches oxidative metabolism to aerobic glycolysis, known as the Warburg effect, in cancer cells [42].