18 Chen Chen YJ YJ Chang Chang LS LS Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells Biochem Pharmacol Biochem Pharmacol 2014 2014 92 92 530 530 543 543 25316568 25316568. The gene discussed is MMP9; the disease is leukemia.