Cytochrome C was found to be activated in the CY-9d 50mg/kg group and the combination group, and treatment with CY-9d 25mg/kg was not found to activate cytochrome C. For other apoptosis-related proteins, such as Bax, Bcl-2, PARP, and cleaved caspase-3 and 9, the increase in CY-9d dosage or combination with AUY-922 was not found to increase tumor growth inhibition or apoptosis-inducing effects. This evidence concerns the gene BAX and neoplasm.