The assessment of the activation of ATM and HA2X, and the content of GPx4 and GSTM in early liver lesions could represent good prognosis factors for aggressive presentations of HCC, although many reports indicate that cancer therapies with antioxidants do not provide benefits, but detriments in some cases, definitively in carcinogenesis processes antioxidants could be fundamental, particularly those serving as precursors for endogenous antioxidants synthesis such as NAC, that cells can manages properly as we previously demonstrated [18] and confirmed in the present work. The gene discussed is GSTM2; the disease is hepatocellular carcinoma.