ATM and hepatocellular carcinoma: Our findings are in agreement with data published by Dr. Calvisi and colleagues [6], indicating that cholesterol homeostasis-related proteins are overexpressed in HCC with poor prognosis, even more RNA-seq analysis of human HCC revealed disorders in lipid metabolism, metabolism of xenobiotics, and ATM signaling [41], some genomic reports also confirm that our mouse data are relevant in human, particularly those related with oxidative stress, DNA damage and lipid metabolism [42].