It is predictable that restoration of the down-regulated Kv4.3 in HF LV is of great importance in normalizing Ca2+ homeostasis and membrane-associated ion channel remodeling via specific inhibition of the compartmentalized CaMKII activity, thus improving E-C coupling and inhibiting ventricular arrhythmias in HF. The gene discussed is CAMK2G; the disease is Ventricular arrhythmia.