It is predictable that restoration of the down-regulated Kv4.3 in HF LV is of great importance in normalizing Ca2+ homeostasis and membrane-associated ion channel remodeling via specific inhibition of the compartmentalized CaMKII activity, thus improving E-C coupling and inhibiting ventricular arrhythmias in HF. This evidence concerns the gene KCND3 and Ventricular arrhythmia.