Conversely, forced expression of E-CADHERIN or knockdown of FIBRONECTIN 1 did not affect the hGH-mediated activation of ERK1/2 in CRC cells, suggesting that E-CADHERIN and FIBRONECTIN 1 function downstream of the hGH-ERK1/2 axis in the CRC cells. The gene discussed is FN1; the disease is colorectal carcinoma.