Exclusion of all conditions together (n=39,599) resulted in similar significant HRs for HCC among patients with ALT levels 40–80, 80–120, and > 120 U/L (2.87 [2.43–3.39], 3.92 [3.07-5.02], and 4.53 [3.53–5.81], respectively; P for trend<0.001). The gene discussed is GPT; the disease is hepatocellular carcinoma.