SOX2 and small cell lung carcinoma: A recent phase I trial of the Smoothened antagonist (sonidegib) in combination with cisplatin/etoposide for advanced SCLC in 15 patients had a response rate of 79%, which is similar to the rate observed in SCLC patients treated with standard chemotherapy alone; but one patient in this group of 15 who was found to have a SOX2 gene amplification remained progression-free on maintenance with sonidegib after 27 months [43].