We previously demonstrated that the Shh pathway is overexpressed in chemo-refractory advanced NSCLC treated with platinum-based chemotherapy, and that inhibition of the Shh pathway with GDC0449 had a synergistic effect with cisplatin in vitro in the most chemo-resistant NSCLC cell lines [41]. The gene discussed is SHH; the disease is non-small cell lung carcinoma.