In addition, deregulated expression and function of epigenetic modifiers such as the enhancer of zeste homolog 2 (EZH2) [16–18], the multiple myeloma SET domain containing-protein (MMSET) [19, 20] and members of the Jumonji C-domain-containing histone demethylases KDM6B [21] and KDM3A [22] are frequently observed in MM. This evidence concerns the gene EZH2 and Miyoshi myopathy.