In vitro, Lyve-1 expression could be induced in murine bone marrow-derived macrophages (BMDM) by stimulation with B16F1 derived tumor-conditioned medium (TCM) in combination with the synthetic glucocorticoid dexamethasone (dexa) and interleukine-4 (IL-4), which have both been described to shape an alternative macrophage phenotype [11]. Here, LYVE1 is linked to neoplasm.