As shown in Figure 6, phosphorylated molecules of the PI3K/Akt/mTOR pathway, and p-PI3K, p-AKT and p-mTOR were upregulated in BC cells treated with IL-22, and increased expression was observed in the presence of both IL-22 and HOXB-AS5 overexpression. The gene discussed is PRAC2; the disease is breast cancer.