IL22 and breast cancer: In MCF-7 cells infected with Lenti-shHOXB-AS5, the expression of HOXB-AS5 induced through IL-22 could be reversed via HOXB-AS5 knockdown (P < 0.001, Figure 4B, right), indicating that IL-22 could specifically upregulate the expression of HOXB-AS5 in BC cells.