AKT1 and breast cancer: Based on a previous study showing that the PI3K-AKT-mTOR signaling pathway plays a critical role in the moderation of proliferation, survival and metabolism in BC [21], we concluded that IL-22 likely promotes the proliferation and invasion of BC cells in a HOXB-AS5-dependent manner through the activation of the PI3K- AKT-mTOR pathway (Figure 7).