Expression analysis in clear cell ovarian cancer tissues revealed that PDI, PDIA6, PDIR, ERp72 and AGR3 were likewise highly expressed compared to normal (p = <0.001), whereas ERp57 expression is statistically less significant (p = <0.05) compared to the above mentioned five proteins in cancerous versus normal tissues (Figure 5B). The gene discussed is PDIA4; the disease is ovarian clear cell cancer.