CD40 and cardiovascular disorder: This phenomenon, such as, can be seen in previous study of genetic association of CD40 gene rs1883832 polymorphism and susceptibility to different types of human cardiovascular diseases, in which association studies of the rs1883832 polymorphism and CAD supported the viewpoint that the rs1883832 CT and CC genotypes were associated with increased risk of CAD [51, 52], however, on the contrary, studies on the association between rs1883832 and IS have demonstrated that the rs1883832 CT and TT genotypes were associated with increased risk of IS [53, 54].