EDNRB and cyclic hematopoiesis: Thus, this outcome revealed that DH was exerting its protecting effect against CH and consequent diseases through ETBR. AT1R is one of the Gq-coupled receptor, located in several cell types including cardiomyocytes, neuronal cells and hepatocytes [27], which is mediating the majority of renin-angiotensin system responses like vasoconstriction, angiogenesis, and aldosterone synthesis [28].