Downstream signal pathways of ETBR and AT1R were consisted of abnormal expressed proteins related with CH, and other key proteins as Mitogen-activated protein kinase 1 (MAPK1), Ras homolog gene family, member A (RHOA), ubiquitin C (UBC) and 2,4-dienoyl-CoA reductase 1 (DECR1) (interaction score larger than 0.5). The gene discussed is RHOA; the disease is cyclic hematopoiesis.