Our working hypothesis (Figure 11) is that within the aggressiveness niche, IL-1β secreted by metabolically stressed, hypoxic and inflamed IRISOE TNBC tumor cells recruits MSCs to the niche (step 1, Figure 11), and activates them to secrete CXCL1 (step 2, Figure 11). The gene discussed is IL1B; the disease is neoplasm.