On the other hand, CXCR2, RAGE, and CXCR1 the receptors of CXCL1, S100A8 and IL-8 secreted in response to activation by IRISOE TNBC cells from MSCs, TAMs, and EC, respectively are only expressed on IRISOE TNBC tumor cells also raises the intriguing possibility that a reciprocal paracrine interaction from the microenvironment to IRISOE TNBC tumor cells also exist. The gene discussed is S100A8; the disease is neoplasm.