Moreover, IHC staining of adjacent sections from 1° IRISOE orthotopic mammary tumors showed that although necrotic areas (see N, Figure 1F) were devoid of IRIS (see N, Figure 1G) they expressed high level of IL-1R (see N, Figure 1H), supporting enhanced expression of IL-1R on the surface of stromal and not necrotic mammary cells. This evidence concerns the gene IL1R1 and breast cancer.