CXCR2 and neoplasm: Including the CXCR2 inhibitor “SB265610” before re-addition to either IRISOE cells significantly decreased the levels of these activated proteins within the tumor cells whether the original CM was from normoxic (compare lanes 1 to 2 in left and right, Figure 2H) or hypoxic (compare lanes 4 to 3 in left and right, Figure 2H) IRISOE cells.