AKT1 and neoplasm: Together suggest IRISOE enhances production/secretion of IL-1β in TNBC tumor cells under normal/normoxic, as well as hypoxic (e.g., within the aggressiveness niche in IRISOE TNBC tumors [35]) conditions through stabilization of HIF-1α and/or activation of AKT, ERK and/or NF-κB signaling.