Indeed, cells overexpressing IRIS show many of the properties of TNBC cells, including high expression of the basal-biomarkers, EMT-inducers, and stemness-enforcers, as well as low expression of the BRCA1 protein, in culture [30, 31], orthotopic mammary tumors [29, 30], as well as human tumor samples [53]. Here, BRCA1 is linked to breast cancer.