FACS analysis with two mouse MSC specific biomarkers; CD29 (expressed by MSC from bone marrow, synovium, and epiphysis origin [50]), and CD90 (expressed by adults mouse MSCs from adipose tissue origin [51]) showed that while vehicle treated IRISOE orthotopic mammary tumor contain ∼20% MSC (white bar, Figure 9B), Anakinra (compare red to white bars, Figure 9B), not SB265610 (compare green to white bars, Figure 9B) decreased that to ∼5%. This evidence concerns the gene ITGB1 and breast cancer.