The data so far suggest that high-level IL-1β secreted by IRISOE TNBC cells activates MSCs to secrete CXCL1 to entrain IRISOE TNBC cells to secrete high-levels CCL2 to activate TAMs to secrete S100A8, and VEGF to activate ECs to secrete IL8, which culminates on formation of aggressive IRISOE TNBC mammary tumors. Here, VEGFA is linked to breast cancer.