Together suggest that IL-1β secreted from IRISOE tumor cells upregulates expression of its own receptor; IL-1R on the surface of naïve MSCs only, leading to activation of AKT, ERK, and p65/NF-κB signaling within MSCs, which leads to secretion of CXCL1 from MSCs. This evidence concerns the gene CXCL1 and neoplasm.