Additionally, other chemokines produced by MSCs, TAMs, and ECs [66] within the IRISOE TNBC aggressiveness niche could enhance tumor growth, promote tumor cells invasion or metastatic capabilities [67-69], in part as we elucidated here by increasing the number of cancer stem cells within that niche [70], and facilitating trans-endothelial migration through production of e.g., VEGF/VEGFR2, or other related mechanisms [71]. This evidence concerns the gene KDR and cancer.