IL1B and breast cancer: The data so far suggest that high-level IL-1β secreted by IRISOE TNBC cells activates MSCs to secrete CXCL1 to entrain IRISOE TNBC cells to secrete high-levels CCL2 to activate TAMs to secrete S100A8, and VEGF to activate ECs to secrete IL8, which culminates on formation of aggressive IRISOE TNBC mammary tumors.