HMGB1 and neoplasm: The uncontrolled release of damaged-associated molecular products (DAMPs) from necrotic tumor cells, such as HMGB1 or DNA from the nucleus, uric acid or RNA from the cytoplasm, DNA or ATP from the mitochondria could promote inflammatory responds in the hypoxic tumors cells in the vicinity by binding to several DAMPs receptors, such as RAGE, TLRs and TREM1 [33].