TP53 and familial pancreatic carcinoma: To explore the growth inhibitory mechansims of CuB, we treated 2 pancreatic cancer cell lines that have different Ras and p53 phenotypes [BxPC-3 (Ras wild-type, p53 mutation) and HPAC (Ras mutation, p53 wild-type)] with varying concentrations of CuB for 24 h.