SPOP and posterior cortical atrophy: To further validate the correctness of aforementioned findings, the big database of cBioportal [30, 31] was used to search for the alteration frequency of SPOP, FH, ELOVL2 and ACADL genes in PCa and analyze the potential correlations of SPOP with FH, ELOVL2 and ACADL. ACTB was used as negative control and ERG was used as positive control.