Importantly, addition of 10 μM AZD5363 not only increased spontaneous cell death in cells co-cultured with CD154-expressing fibroblasts, but also restored sensitivity of CD40-stimulated CLL cells to bendamustine-induced killing to the levels seen in the CLL cells co-cultured with control fibroblasts at both time points (Figure 2A and 2B). The gene discussed is CD40; the disease is B-cell chronic lymphocytic leukemia.