This pattern is strikingly similar with coronary artery disease patients having high risk of cardiovascular death, as we have shown that higher Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0) and Cer(d18:1/24:1) ceramides predict increased risk, while Cer(d18:1/24:0) is a protective lipid for cardiovascular events [16, 17]. This evidence concerns the gene CBLN1 and coronary artery disorder.