They combine an FGFR3 portion lacking only a small part at the C-terminus and variable portions of Transforming Acid Coiled-Coil containing protein 3 (TACC3); for example, a fusion found in a bladder cancer cell line RT112, that is also frequently observed in other tumours, comprises amino acids 1–760 of FGFR3 (IIIb isoform) fused in-frame to amino acids 648–838 of TACC3 [9, 12]. Here, TACC3 is linked to urinary bladder cancer.