FGFR3 and urinary bladder cancer: For example, as previously reported for several activating FGFR3 point-mutations, NIH3T3 cells expressing FGFR3-TACC3 show a transformed phenotype that was not observed in telomerase-immortalised normal human urothelial cells (TERT-NHUC) used in studies of initiation and development of bladder cancer, where major changes attributed to mutated FGFR3 include increased survival and proliferation to high cell density [9, 18, 19].