We and others previously have shown that activation of p53 causes a mesenchymal-epithelial-transition (MET) in CRC cell lines, at least in part, by transcriptional activation of the miR-34 and miR-200 microRNA families and subsequent repression of EMT-inducing transcription factors, such as SNAIL and ZEB1 [38-41]. The gene discussed is ZEB1; the disease is colorectal carcinoma.