Moreover, LINC01021 expression is associated with a p53-dependent gene expression signature in CRC patient samples, further supporting the notion that LINC01021 expression in CRC is dependent on the presence of wild-type p53. Using a CRISPR/Cas9 approach, we could show that deletions of promoter sequences eliminating the p53 binding site severely reduced both basal and p53-induced LINC01021 expression in wild-type p53 CRC cells. This evidence concerns the gene TP53 and colorectal carcinoma.