PRMT5 and breast cancer: Surprisingly, none of our top differentially expressed validated genes appeared to have a close correlation with breast cancer pathogenesis (Figures S5B and S5C), and although CDKN1A was validated as a PRMT5-repressed gene (Figure S6B), the functional significance of this is unclear given that the cell cycle profiles of shCTRL or PRMT5-depleted AR cells were indistinguishable (Figure 3F).