AKT1 and cancer: KEGG pathway analysis of enriched genes suppressed by PRMT5 (i.e., those that were upregulated after shRNA depletion) identified cancer pathways and signaling pathways (including cGMP-PGK, PI3K-AKT, ErbB, and FoxO pathways) (Figure S5D), while metabolic genes are predominantly induced by PRMT5 (ALDOC, HK2, TSTA3, and ALDH3A1; Figure S5E).