As with HRECs, diabetes increased H3K27me3 levels at the MMP-9 promoter by approximately 4-fold, and this was accompanied by an increase in Ezh2 recruitment at the same site of the promoter (Fig. 7a); accompanying gel picture (Fig. 7b) represents the band intensity on a 2% agarose gel. The gene discussed is MMP9; the disease is diabetes mellitus.