EZH2 and ovarian carcinoma: In addition, similar crosstalk between histone methylation-DNA methylation of the intracellular inhibitor of MMP-9, TIMP1, in regulating MMP-9 activity also cannot be ruled out; Ezh2-mediated transcriptional repression of TIMPs is considered to be one of the major mechanisms shifting the MMPs-TIMPs balance and MMPs activation in invasive prostate cancer,45 and as mentioned above, in ovarian cancer, overexpression of Ezh2 increases recruitment of Dnmts at the TIMP2 promoter.44