In addition, similar crosstalk between histone methylation-DNA methylation of the intracellular inhibitor of MMP-9, TIMP1, in regulating MMP-9 activity also cannot be ruled out; Ezh2-mediated transcriptional repression of TIMPs is considered to be one of the major mechanisms shifting the MMPs-TIMPs balance and MMPs activation in invasive prostate cancer,45 and as mentioned above, in ovarian cancer, overexpression of Ezh2 increases recruitment of Dnmts at the TIMP2 promoter.44 This evidence concerns the gene TIMP2 and ovarian cancer.