Animal models have clearly documented that apoptosis of retinal cells, including vascular and nonvascular cells, proceeds the development of histopathology characteristic of diabetic retinopathy,1–3 and mitochondrial damage is implicated in the accelerated apoptosis of capillary cells.4,5 Our previous work has shown that diabetes activates gelatin matrix metalloproteinases (MMP-2 and MMP-9) in the retina and its capillary cells, and this activation is an early event in the pathogenesis of diabetic retinopathy. The gene discussed is MMP2; the disease is diabetes mellitus.