Aβ load and Aβ plaque numbers as well as tau hyperphosphorylation have been found to be dramatically increased in hippocampus and frontal cortex from 9–12 months olds old 3xTg-AD mice compared to 6 months old animals [36], and the mice also develop synaptic dysfunctions, including LTP deficits, in an age-dependent manner [17]. The gene discussed is MAPT; the disease is Alzheimer disease.