CHRNA7 and early-onset autosomal dominant Alzheimer disease: The degrees of α7 nAChR/NMDAR complex formation in cortical homogenates from healthy control (non-Alzheimer’s Disease [non-AD]) and AD humans and in wild-type (WT) and 3xTg-AD mice brain cortical homogenates have been also compared, and the molecular mechanism underlying the observed differences in complex formation between these tissues has been investigated.