However, the key role of Aβ1–42 for AD pathology [40, 41] and the clear age-dependent nature of the observed reduction in GluN1/α7 ratios in the BGT pull-down samples from 3xTg-AD cortex (Figs 3 and 4) prompted us to investigate the effect of the peptide on the formation of this putative complex. Here, GRIN1 is linked to Alzheimer disease.