The degrees of α7 nAChR/NMDAR complex formation in cortical homogenates from healthy control (non-Alzheimer’s Disease [non-AD]) and AD humans and in wild-type (WT) and 3xTg-AD mice brain cortical homogenates have been also compared, and the molecular mechanism underlying the observed differences in complex formation between these tissues has been investigated. Here, CHRNA7 is linked to Alzheimer disease.