In contrast to the significant differences observed between total α7 and GluN1 expression in AD and non-AD cortical homogenates, the expression levels of the two subunits in cortical homogenates from adult 3xTg-AD mice (76–84 weeks old) and age-and sex-matched nontransgenic controls were highly comparable (Fig 3A–3C). This evidence concerns the gene GRIN1 and Alzheimer disease.