Another pertinent question is whether the nanomolar concentrations of oligomeric Aβ1–42 antagonizing the α7 nAChR/NMDAR complex formation in human cortical homogenate can be said to be reconcilable with the reduced GluN1/α7 ratios observed in cortical tissues from the AD brain and adult 3xTg-AD mouse brain. Here, GRIN1 is linked to Alzheimer disease.