GRIN1 and Alzheimer disease: Interestingly, in contrast to the different levels of GluN1 pulled-down with α7 from adult 3xTg-AD and adult WT mouse cortical homogenates, the GluN1/α7 ratios determined in the BGT pull-down samples from cortical homogenates from young 3xTg-AD and young WT mice were highly similar (Fig 4E).