Based on our previous research which identified an increase in plasma sCD127 in HIV infection, and our preliminary understanding of how IL-7 induces sCD127 release from T-cells[18, 29], we questioned the effect of IL-7 therapy on plasma sCD127 concentrations, and whether the soluble receptor was associated with the therapeutic effects of IL-7 on T-cells in HIV infection. Here, IL7 is linked to HIV infectious disease.