PRNP and prion disease: Further, several kinases known to affect FAT are reportedly deregulated in prion diseases, including GSK3 [29], PI3K [30], JNK [31], and casein kinase 2 (CK2) [32, 33], Based on these precedents, we set out to determine whether PrP-FL inhibits FAT directly and, if so, determine whether specific protein kinases mediate such effects.