Recent progress in genome-wide association studies (GWASs) has uncovered at least 16 susceptibility loci for POAG, although most investigations were performed in cohorts of Caucasian ancestry.[8–12] Several GWASs targeting POAG in Asians have been reported.[13–19] These studies have uncovered a few disease-associated loci, including those near ABCA1, PMM2 and CDC7/TGFBR3.[18,19] In Japan, a few GWASs have shown variable results.[13–17] Only the susceptibility loci at 9p21 (near CDKN2B-AS1) and 14q23 (near SIX6) appear to be reproducible so far. This evidence concerns the gene SIX6 and open-angle glaucoma.