At 18 h, the renal function of the IL-18Rα KO mice that received a transfer of CD4+ T cells and F4/80+ cells from WT mice showed more severe AKI, manifested by a remarkable rise in BUN, compared to IL-18Rα KO mice: WT 108.6 ± 5.9; IL-18Rα KO (that received CD4+ T cells) 95.4 ± 2.3; and IL-18Rα KO (with F4/80+ cells) 88.1 ± 1.4 vs. IL-18Rα KO 63.4 ± 8.0 mg/dL. Here, CD4 is linked to acute kidney injury.