AOC3 and metastatic malignant neoplasm in the lymph nodes: In HER-2-negative breast cancer, AOC3 negativity was associated with short DFS and OS (p = 0.026 and p = 0.037, respectively), and in the breast cancer showing lymph node metastasis, AOC3 negativity was associated with short DFS and OS (p = 0.038 and p = 0.012, respectively) (Figure 5).