MMP14 and glioblastoma: Actually, it had been already suggested that the cells of the monocytic lineage, including monocytes, macrophages and microglia, were particularly affected by glioma cells; these effects, (namely increased cytokine secretion, increased phagocytic capacity of macrophages and increased expression of MT1-MMP by microglial cells) were mediated by EVs of glioblastoma origin but not by EVs of non-glioblastoma origin [316].