SKA2 and neoplasm: For example, miR-141 targets Spindle and Kinetochore Associated protein 2 (SKA2) and functions as a tumor suppressor [237]; similarly, miR-370 targets beta-catenin and cyclin E2 (CCNE2), thus acting as a tumor suppressor as well [256,257]; on the other hand, LncRNAs HOTAIR (HOX transcript antisense RNA) and KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1) target, respectively, miR-141 [237,263,264] and miR-370 [257], acting as oncogenic factors (Table 2 and Table 3).