MMP2 and central nervous system cancer: Actually, NF-κB has been reported to activate genes involved in mesenchymal transition, such as Snail, ZEB1, ZEB2, Twist, MMP-2 and MMP-9 [120] and, in general, genes encoding for proteins able to potentiate glioma cell ability to invade surrounding parenchyma, such as the TNF-like weak inducer of apoptosis (TWEAK-Fn14) [121].