In glioblastoma (GBM) and anaplastic astrocytomas, WNT signaling is misregulated and both β-catenin and the transcription factor 4 (TCF4) show abnormal expression levels [104]; in particular, increased nuclear amount of β-catenin are found in those patients presenting the mesenchymal type of GBM [105]. Here, TCF4 is linked to glioblastoma.