Some of the proteins present in EVs more strictly correlate with the hypoxic state of the glioma cells; among these proteins, in addition to those, already mentioned, which are involved in ECM remodeling and angiogenesis, caveolin (CAV), lysyl oxidase and interleukin 8 (IL8) have been also found [318]. The gene discussed is CXCL8; the disease is central nervous system cancer.