NFKB1 and central nervous system cancer: Recently, it was found, for example, which netrin-1, a protein probably involved in axon guidance during brain development, is highly expressed in glioma cells, in a tumor grade-dependent way; it was suggested that netrin-1 activates NF-κB in an Unc5 netrin receptor A-dependent route, resulting in increased c-Myc expression [123].