Importantly, the observed lower levels of expansion of Lym-1 CAR T cells during manufacture did not reduce proliferation upon recognition of the Lym-1 epitope: Lym-1 and CD19 CAR T cells proliferated at the same rate when cultured with irradiated tumor cell lines expressing the Lym-1 and CD19 epitopes in the absence of exogenous cytokines (Figure 7). The gene discussed is CD19; the disease is neoplasm.