PGP and colonic neoplasm: We recently reported that DHA and EPA were highly incorporated in the lipid rafts of colon cancer HT9/MDR cells [73]: following this incorporation, they reduced the amount of total membrane- and lipid raft-associated Pgp and MRP1 (another ABC transporter enriched in rafts [83]), restoring the chemosensitivity to doxorubicin and irinotecan.