For instance, ω-3 and ω-6 LCPUFAs decreased the transcription of Pgp in colorectal cancer cells: such a decrease, however, was very small if compared with the marked increased efficacy of paclitaxel, a substrate of Pgp, induced by LCPUFAs in these cells [91], leading to the hypothesis that the changes in Pgp activity or distribution of more than in Pgp expression, are mainly responsible for chemosensitization. The gene discussed is PGP; the disease is colorectal cancer.