CDH2 and neoplasm: When tumor cells undergo EMT, they lose epithelial characteristics and obtain mesenchymal properties including morphologic alteration which is often accompanied by the dissolution of epithelial tight junction, loss of cell adhesion, down-regulated expression of some epithelial markers such as E-cadherin as well as the acquisition of mesenchymal cadherins, for example, upregulated vimentin and N-cadherin (Hazan et al., 2004; Qi et al., 2016).