CDKN2A and glomerulosclerosis: Importantly, in hypertension, DN, MG, IgAN, FSGS and also in DGF after renal transplantation, senescent cell accumulation correlated with renal histopathological changes (glomerulosclerosis, tubular atrophy, and interstitial fibrosis), with renal function, and/or with proteinuria, while in IgAN, tubular expression of p16, p21 and SA-beta-gal also correlated with blood pressure(Liu et al. 2012b).