Over the past decades, Akt-mTOR signaling has increasingly garnered a central role in regulating several molecular and biochemical pathways which are known to be altered in a variety of pathological conditions encompassing obesity, cardiovascular diseases, hypertension, type II diabetes, neurodegeneration, and brain tumors [37, 38, 66, 67, 111]. The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.