In the present study, four SNPs of VDR, Bsm I (rs1544410), Taq I (rs731236), Apa I (rs7975232), and Fok I (rs10735810), were genotyped with the restriction fragment length polymorphism (RFLP) analysis method, aiming to find association between dental caries and VDR gene polymorphisms in Chinese adolescents. Here, VDR is linked to dental caries.