RUNX3 and colorectal carcinoma: The CIMP CRC subtype associates with a high frequency of CpG hypermethylation and is diagnosed based on the methylation status of various genes that participate in regulation of calcium transport (CACNA1G), proliferation (IGF2), Wnt signaling (NEUROG1), transcription activity (RUNX3), and suppression of cytokine signaling (124, 125).