In HCT-8 CRC cells, the compound (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid derived from chicory root increased apoptosis associated with activation of caspases (-3, -8, and -9) (82) and B-cell lymphoma-2 (BCL-2)-4 [Bcl-2-associated X protein (BAX)]; and downregulation of BCL-2 and NF-κB (82). The gene discussed is BCL2; the disease is colorectal carcinoma.